Previous study has assessed patient awareness about management of sickle cell disease (SCD) which indicates that there is a lack of awareness about the disease and possibly a need for more awareness. Therefore, our study aimed at Awareness & Knowledge of Sickle Cell Disease in Rivers State, Nigeria. The study was conducted from October 2018 to February 2019. A questionnaire was distributed among 154 persons selected from among the general public. Most (75.0%) had heard of SCD and 35.0% knew that it can be diagnosed by a blood test, but 33.3% did not know the prevalence of SCD in Nigeria. 50(41.7%) recognized it as a hereditary disorder. Professional/university students gave the most correct answers; Females showed better knowledge than males and married persons seems to know more about SCD than unmarried ones. There is a fair level of knowledge about SCD among the respondents, though some of the respondents were confused about the difference between the carrier state of a disease and the disease itself. Health education should be intensified to impact sufficient comprehensive knowledge about SCD to enable the public take informed decision about their marriage so as to prevent procreation of children affected with SCD.